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psd95  (Cell Signaling Technology Inc)


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    Structured Review

    Cell Signaling Technology Inc psd95
    Modulation of synaptic plasticity protein expression by L-lactate and GPR81 agonist in primary hippocampal cells. (a) Exemplary immunoblotting analysis. (b-d) Bar graphs depict the quantified protein levels (normalized to CON) for BDNF, SYN, and <t>PSD95,</t> derived from three independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01 versus the CON group.
    Psd95, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 654 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rabbit+anti+psd95/PSD95+XP+Rabbit+mAb/pmc13658191-116-36-38
    Average 96 stars, based on 654 article reviews
    psd95 - by Bioz Stars, 2026-10
    96/100 stars

    Images

    1) Product Images from "Lactate promotes mitochondrial biogenesis and fusion via GPR81 to enhance synaptic plasticity-related protein expression in hippocampal cells"

    Article Title: Lactate promotes mitochondrial biogenesis and fusion via GPR81 to enhance synaptic plasticity-related protein expression in hippocampal cells

    Journal: Frontiers in Cell and Developmental Biology

    doi: 10.3389/fcell.2026.1929409

    Modulation of synaptic plasticity protein expression by L-lactate and GPR81 agonist in primary hippocampal cells. (a) Exemplary immunoblotting analysis. (b-d) Bar graphs depict the quantified protein levels (normalized to CON) for BDNF, SYN, and PSD95, derived from three independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01 versus the CON group.
    Figure Legend Snippet: Modulation of synaptic plasticity protein expression by L-lactate and GPR81 agonist in primary hippocampal cells. (a) Exemplary immunoblotting analysis. (b-d) Bar graphs depict the quantified protein levels (normalized to CON) for BDNF, SYN, and PSD95, derived from three independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01 versus the CON group.

    Techniques Used: Expressing, Western Blot, Analysis, Derivative Assay

    Effects of mitochondrial dysfunction on expression of genes and proteins related to synaptic plasticity in Neuro-2A cells. (a-e) Quantitative analysis (qRT-PCR) of Arc , Fos , Egr1 , bdnf , and Syp , derived from three independent replicates. (f) Exemplary Western blot image. (g-i) Bar graphs depict the quantified protein levels for BDNF, SYN, and PSD95, derived from six independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001 versus the LA group. # p < 0.05, ## p < 0.01, ### p < 0.001 versus the 3OBA group. n. s., no significant difference.
    Figure Legend Snippet: Effects of mitochondrial dysfunction on expression of genes and proteins related to synaptic plasticity in Neuro-2A cells. (a-e) Quantitative analysis (qRT-PCR) of Arc , Fos , Egr1 , bdnf , and Syp , derived from three independent replicates. (f) Exemplary Western blot image. (g-i) Bar graphs depict the quantified protein levels for BDNF, SYN, and PSD95, derived from six independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001 versus the LA group. # p < 0.05, ## p < 0.01, ### p < 0.001 versus the 3OBA group. n. s., no significant difference.

    Techniques Used: Expressing, Analysis, Quantitative RT-PCR, Derivative Assay, Western Blot

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    Article Title: Dysfunction of α2δ4 leads to photoreceptor degeneration through disrupted synaptic mitochondria and calcium crosstalk.
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    Image Search Results


    Modulation of synaptic plasticity protein expression by L-lactate and GPR81 agonist in primary hippocampal cells. (a) Exemplary immunoblotting analysis. (b-d) Bar graphs depict the quantified protein levels (normalized to CON) for BDNF, SYN, and PSD95, derived from three independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01 versus the CON group.

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Lactate promotes mitochondrial biogenesis and fusion via GPR81 to enhance synaptic plasticity-related protein expression in hippocampal cells

    doi: 10.3389/fcell.2026.1929409

    Figure Lengend Snippet: Modulation of synaptic plasticity protein expression by L-lactate and GPR81 agonist in primary hippocampal cells. (a) Exemplary immunoblotting analysis. (b-d) Bar graphs depict the quantified protein levels (normalized to CON) for BDNF, SYN, and PSD95, derived from three independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01 versus the CON group.

    Article Snippet: Following transfer, membranes were blocked and incubated overnight at 4 °C with the indicated primary antibodies: GPR81 (1:400, Sigma, SAB1300790), p-ERK1/2 (1:1000, CST, 4370), ERK1/2 (1:1000, CST, 4695), BDNF (1:1000, Proteintech, 28205-1-AP), SYN (1:1000, CST, 4329), PSD95 (1:1000, CST, 3450), PGC-1α (1:1000, Novus, NBP1-04676SS), NRF1 (1:1000, CST, 46743), NRF2 (1:1000, CST, 12721), TFAM (1:2000, Abcam, ab131607), OPA1 (1:1000, CST, 8047), MFN1 (1:2000, Proteintech, 13798-1-AP), MFN2 (1:1000, CST, 9482), and β-Tubulin (1:2000, Proteintech, 10068-1-AP).

    Techniques: Expressing, Western Blot, Analysis, Derivative Assay

    Effects of mitochondrial dysfunction on expression of genes and proteins related to synaptic plasticity in Neuro-2A cells. (a-e) Quantitative analysis (qRT-PCR) of Arc , Fos , Egr1 , bdnf , and Syp , derived from three independent replicates. (f) Exemplary Western blot image. (g-i) Bar graphs depict the quantified protein levels for BDNF, SYN, and PSD95, derived from six independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001 versus the LA group. # p < 0.05, ## p < 0.01, ### p < 0.001 versus the 3OBA group. n. s., no significant difference.

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Lactate promotes mitochondrial biogenesis and fusion via GPR81 to enhance synaptic plasticity-related protein expression in hippocampal cells

    doi: 10.3389/fcell.2026.1929409

    Figure Lengend Snippet: Effects of mitochondrial dysfunction on expression of genes and proteins related to synaptic plasticity in Neuro-2A cells. (a-e) Quantitative analysis (qRT-PCR) of Arc , Fos , Egr1 , bdnf , and Syp , derived from three independent replicates. (f) Exemplary Western blot image. (g-i) Bar graphs depict the quantified protein levels for BDNF, SYN, and PSD95, derived from six independent replicates. Data are expressed as mean ± SD. Statistical significance: * p < 0.05, ** p < 0.01, *** p < 0.001 versus the LA group. # p < 0.05, ## p < 0.01, ### p < 0.001 versus the 3OBA group. n. s., no significant difference.

    Article Snippet: Following transfer, membranes were blocked and incubated overnight at 4 °C with the indicated primary antibodies: GPR81 (1:400, Sigma, SAB1300790), p-ERK1/2 (1:1000, CST, 4370), ERK1/2 (1:1000, CST, 4695), BDNF (1:1000, Proteintech, 28205-1-AP), SYN (1:1000, CST, 4329), PSD95 (1:1000, CST, 3450), PGC-1α (1:1000, Novus, NBP1-04676SS), NRF1 (1:1000, CST, 46743), NRF2 (1:1000, CST, 12721), TFAM (1:2000, Abcam, ab131607), OPA1 (1:1000, CST, 8047), MFN1 (1:2000, Proteintech, 13798-1-AP), MFN2 (1:1000, CST, 9482), and β-Tubulin (1:2000, Proteintech, 10068-1-AP).

    Techniques: Expressing, Analysis, Quantitative RT-PCR, Derivative Assay, Western Blot